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Title   위암 환자의 혈액 및 조직에서 Urokinase-type Plasminohen Activator 발현의 임상적 의의 ( Clinical Significance of Urokinase-type Plasminohen Activator(uPA) Expression from Serum and Tissue of Gastric Cancer Patients )
Publicationinfo   1997 Jan; 029(05): 765-774.
Key_word   uPA, PAI-1, Gastric cancer, Serum, Tissue
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Abstract   Purpose: We measured the gastric cancer tissue uPA and plasminogen activator inhibitor-1 (PAI-1) levels and compared them to those of the peripheral and portal blood levels to evaluate the correlation. Materials and Methods: Tissue uPA and PAI-1 levels were measured by ELISA assay (Monozyme, Netherland) in paired 85 normal and cancer tissues resected from gastric cancer patients. In 50 patients, blood uPA and PAI-1 levels were measured from pre-operative peripheral and portal blood, post-operative portal blood. Results: Gastric cancer tissue uPA and PAI-1 levels increased from the early stage. The elevated cancer-to-normal ratios of the uPA and PAI-1 were constant from stage I to IV. There were correlations of uPA between normal and cancer tissues(r2=0.38) and between peripheral and pre-resection portal blood level(r2=0.64). There were no correlations betwe- en tissue PAI-1 level and blood PAI-1 levels. However, there were correlations in PAI- 1/uPA ratio between cancer tissue and peripheral blood(r2=0.25), peripheral blood and pre- resection portal blood(r2=0.60). Conclusion: Even if the cancer tissue levels of uPA and PAI-1 increased from the early stage of gastric cancer, only blood uPA level correlated with tissue uPA level. A modest correlation found in PAI-1/uPA ratio between cancer tissue and blood suggests applicability of blood PAI-1/uPA ratio in predicting tissue uPA, PAI-1 expression.
저 자   정현철(Hyun Chul Chung),박준오(Joon Oh Park),권현자(Hyun Ja Kwon),김태수(Tae Soo Kim),정희철(Hee Chul Chung),공수정(Soo Jung Kong),이화영(Hwa Young Lee),라선영(Seon Young Rah),유내춘(Nae Choon Yoo),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),노성훈(Sung Hoon Roh),민진식(Jin Sik Min),,김병수(Byung